Before submitting your pages to search engines, the most important task is to select the right keywords to get your website in search result. Keywords which will best way describe your site and which will bring visitors to your web page. you should be very careful about choosing right keyword. After you make your own list of keywords, ask your friends to give you their suggestions and feedback. Use a thesaurus or dictionary. Some words may make perfect sense to you but may not to others and vice versa. After you choose them, add plurals of the same keywords. Always try to use keyword phrases so they make sense when they are put together. The key to successful promotion through search engines is to have the right keywords implemented at all the right places on your Web Page.

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good looking out another important thing to remeber is key words in the domain especially if its product related

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it is not necessary that your domain contains the keyword you are targeting.

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you may want include at least one keyword it is crucial that key words in the domain is present http://videos.webpronews.com/2006/11/10/advice-from-an-seo-expert/ the top seo from web pro explains the foremost on thought of there he breaks it down clearly.

Thanks

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I just try to think of everything related to my site, even if I know its a strong keyword that isn't relevant I still would use it in some cases